Antimitogenic effect of Larrea di6aricata Cav.: participation in arachidonate metabolism

CLAUDIA ANESSINI ; ANA MARÍA GENARO; GRACIELA ALICIA CREMASCHI; LEONOR STERIN-BORDA; ENRI SANTIAGO BORDA

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. C, COMPARATIVE PHARMACOLOGY AND TOXICOLOGY.

Elsevier Science

Lugar: Nueva York; Año: 1999 vol. 122 p. 245 - 252

0742-8413

Aqueous extracts of the leaves of Larrea di6aricata Cav. exert antimitogenic effects on tumor cells (BW 5147 murine immature T-lymphoma) and normal, stimulated lymphocytes. The effective concentration was four times smaller in the case of tumor cells than in the case of normal, stimulated lymphocytes. Inhibitor studies of arachidonate pathway suggest that the proliferative effect of the extract is due to the activation of lipoxygenase metabolism, while the inhibitory action could be a direct effect.