Origanum vulgare : peroxidase-, superoxide dismutase- and immunomodulatory activities on macrophages activated with Helicobacter pylori derivatives

FERRAMOLA, FLORENCIA FÁTIMA; MARRASSINI, CARLA; ALONSO, MARÍA ROSARIO; MATTAR DOMINGUEZ, MARÍA AIDA; VEGA, ALBA EDITH; ANESINI, CLAUDIA

NATURAL PRODUCT RESEARCH

TAYLOR & FRANCIS LTD

Año: 2023 p. 1 - 9

1478-6419

Helicobacter pylori, invades the gastric mucosa and is one of the causative agents of stomach cancer and peptic ulcers. Origanum vulgare, is a flavouring herb used worldwide. But little is knownabout the effects of extracts prepared by maceration in cold PBS. This study was aimed at determining the superoxide dismutase (SOD)- and peroxidase (Px)-like antioxidant activities as well as the immunomodulatory activity (anti-inflammatory/pro-inflammatory) of an aqueous extract of O. vulgare by evaluating the production of nitric oxide (NO) in macrophages stimulated with H. pylori derivatives. The cold extract presented SOD-like and Px-like activities with effective concentration 50 (EC50) values of Px = 489.7 ± 48 μg/ml and SOD= 384.7 ± 30 μg/ml. The extract was also capable of modulating the production of NO in macrophages stimulated by H. pylori derivatives by exerting a pro-inflammatory activity at high concentrations and an anti-inflammatory activity at low concentrations.