Vascular and Autonomic Function as Early Predictive Biomarkers of the Progression to Gestational Hypertension

CLAUDIO JOO TURONI; SILVIA BENVENUTO; RODRIGO O MARAÑÓN; ROSSANA CHAHLA; PERAL DE BRUNO MARIA

European Journal of Obstetrics & Gynecology and Reproductive Biology: X

Elsevier

Año: 2023 vol. 20

2590-1613

BackgroundThe changes in endothelial function, arterial stiffness, and heart rate variability (HRV) produced in the first trimester of pregnancy in women who develop gestational hypertension (GH) are still being investigated. Objective: to evaluate the HVR, endothelial function, and arterial stiffness changes during the first trimester of pregnancy and their relationship with the development of GHMethodsA group of women normotensive during the first trimester (n=43), who later did (GH; n=11) or did not (no-GH; n=32) develop GH in that pregnancy, were enrolled. In the first trimester, endothelial function and arterial stiffness were evaluated through photoplethysmography. HRV, parasympathetic (PNS), and sympathetic (SNS) indexes were measured in a 5-minute continuous electrocardiogram record at rest sitting. The Griess reaction measured urinary nitrite excretion (NOx).ResultsSystolic blood pressure (SBP) values were higher in GH (no-GH: 105.8±2.0 vs. GH: 112.7±3.0 mmHg; p