Magnetic SiO2-Mn1-xCoxFe2O4 nanocomposites decorated with Au@ Fe3O4 nanoparticles for hyperthermia

VIVIANA DABOIN; SARAH BRICEÑOS; JORGE SUAREZ; GEMA GONZALEZ

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2019 vol. 479 p. 91 - 98

0304-8853

The design of multicore magnetic nanocomposites for hyperthermia therapy is still far from being optimized due tothe variable performance found in many iron oxide nanostructure systems. Herein, we present a reproducible synthesisof magnetic mixed manganese-cobalt ferrite nanoparticles Mn1−xCoxF e2O4 (0 ≤ x ≤ 1) coated with silica (SiO2) anddecorated with Au@F e3O4 nanoparticles as magnetic fluid hyperthermia heat mediators, employing a hydrogel as atissue-equivalent. Mn1−xCoxF e2O4 NPs were synthesized using the thermal decomposition method, then coated withSiO2 following the St¨ober method and decorated with Au@F e3O4 nanoparticles. Structural characterization was carriedout applying X-ray diffraction (XRD), infrared spectroscopy (FTIR), and transmission electron microscopy (TEM).Magnetic properties as a function of the Mn+2 content were studied using a vibrating sample magnetometer (VSM)at room temperature. Hyperthermia investigations were performed at 454 ± 20 kHz with a magnetic field amplitudeof up to 5.5 mT. The specific absorption rate (SAR) values of the nanocomposites were found to have increased withthe Au@F e3O4 decoration in water. The advantage of the designed nanocomposite system lies in the fact that versatilecombinations of magnetic NPs, SiO2 and Au@F e3O4 can change the magnetic properties to optimize the SpecificAbsorption Rate (SAR).