Characterization of lesions of nutritional congenital goitre in cattle

COLQUE-CARO, LUIS A.; ACUÑA, FRANCISCO; AGUIRRE, LAURA S.; AVELLANEDA-CÁCERES, AGUSTÍN; BARBEITO, CLAUDIO G.; SIGNORINI, MARCELO; MOORE, DADIN P.; MICHELOUD, JUAN F.

JOURNAL OF COMPARATIVE PATHOLOGY

ELSEVIER SCI LTD

Año: 2023 vol. 206 p. 1 - 8

0021-9975

There are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 39 bovine TGs (fetuses [9], stillbirths [18], neonates [12]) born to dams with low T4 hormone levels and no iodine supplementation and 10 (fetuses [3], stillbirths [3], neonates [4]) born to dams with normal T4 levels and supplemented with iodine. Body weight (BW), TG weight (TGW), TGW:BW ratio and histological lesions were determined. The TGs were classified histopathologically as normal gland (G0), mild goitre (G1), moderate goitre (G2) or severe goitre (G3). Various morphological and morphometric parameters were calculated from microscopic images using image analysis software. Immunohistochemistry was performed to detect proliferating cell nuclear antigen (PCNA). There were significant differences in the TGW:BWratio among groups (P