FARMACOTERAPIA EN REHABILITACIÓN TEMPRANA POSTERIOR AL ACCIDENTE CEREBROVASCULAR ISQUÉMICO

PIGRETTI SANTIAGO; MARIA LOURDES POSADAS MARTINEZ

MEDICINA (BUENOS AIRES)

MEDICINA (BUENOS AIRES)

Lugar: Buenos Aires; Año: 2023

0025-7680

Mariana Riveros 6 2, Virginia Tejada Jacob 7 2, Miriam Weinberg 8 9, Maria L Posadas Martinez 10 11, Delfina Cirelli 10, Mariana A Burgos 10, Máximo Zimerman 12, Marina Romano 8 2Affiliations collapseAffiliations1Hospital Central de Mendoza, Argentina. E-mail: spigretti@gmail.com.2Miembro Sociedad Neurológica Argentina.3Clínica Modelo Lanús, Buenos Aires, Argentina.4Hospital Provincial del Centenario, Rosario, Santa Fe, Argentina.5Hospital Dr. César Milstein, Buenos Aires, Argentina.6Hospital Dr. G. Rawson, San Juan, Argentina.7Instituto de Neurología Cognitiva (INECO), Neurociencias Oroño, Rosario, Santa Fe, Argentina.8Centro de Educación Médica e Investigación Clínica Norberto Quirno (CEMIC), Buenos Aires, Argentina.9Miembro Sociedad Argentina de Medicina Física y Rehabilitación.10Área de Investigación no patrocinada, Departamento de Investigación, Hospital Italiano de Buenos Aires, Argentina.11Miembro Sociedad Argentina de Investigación Clínica.12Instituto de Neurología Cognitiva (CITES INECO), Buenos Aires, Argentina.PMID: 37624681Free articleAbstract in English, SpanishThere is a wealth of information on early pharmacological supportive treatment for early rehabilitation following acute ischemic stroke. This review aims to provide healthcare professionals involved in rehabilitating patients with a summary of the available evidence to assist with decision-making in their daily clinical practice. A search for randomized clinical trials and observational studies published between 1/1/2000 and 28/8/2022 was performed using PubMed, Cochrane and Epistemonikos as search engines with language restriction to english and spanish. The selected studies included patients older than 18 with acute ischemic stroke undergoing early rehabilitation. The outcomes considered for efficacy were: motor function, language, and central pain. The selected pharmacological interventions were: cerebrolysin, levodopa, selegiline, amphetamines, fluoxetine, citalopram, escitalopram, antipsychotics, memantine, pregabalin, amitriptyline and lamotrigine. Evidence synthesis and evaluation were performed using the GRADE methodology. This review provided a summary of the evidence on pharmacological supportive care in early rehabilitation of post-acute ischemic stroke patients. This will make it possible to improve current recommendations with the aim of collaborating with health decision-making for this population.Keywords: acute ischemic stroke; neurological rehabilitation; stroke rehabilitation.