Isolation and Antimacrofouling Activity of Indole and Furoquinoline Alkaloids from ‘Guatambú’ Trees ( Aspidosperma australe and Balfourodendron riedelianum )

PÉREZ, MIRIAM; PIS DIEZ, CRISTIAN M.; BELÉN VALDEZ, MARÍA; GARCÍA, MÓNICA; PAOLA, ANALÍA; AVIGLIANO, ESTEBAN; PALERMO, JORGE A.; BLUSTEIN, GUILLERMO

Chemistry and Biodiversity

WILEY-V C H VERLAG GMBH

Año: 2019

1612-1872

In this work, the antifouling activity of five alkaloids, isolated from trees of the Atlantic rainforest, was studied.The tested alkaloids were olivacine (1), uleine (2) and N-methyltetrahydroellipticine (3) from Aspidospermaaustrale (?yellow guatambú?) and the furoquinoline alkaloids kokusaginine (4) and flindersiamine (5) fromBalfourodendron riedelianum (?white guatambú?). All these compounds can be isolated from their natural sourcesin high yields in a sustainable way. The five compounds were subjected to laboratory tests (attachment test ofthe mussel Mytilus edulis platensis) and field trials, by incorporation into soluble matrix paints, and 45 days ofexposure of the painted panels in the sea. The results show that compound 3 is a very potent antifoulant, andthat compounds 4 and 5 are also very active, while compounds 1 and 2 did not show any significant antifoulingactivity. These results open the way for the development of environmentally friendly antifouling agents, basedon abundant and easy-to-purify compounds that can be obtained in a sustainable way.