CONICET | Buscador de Institutos y Recursos Humanos

The antifouling activity of peracetylated cholic acid (1), a bile acid derivative which was isolated in aprevious work as a natural product from the Patagonian sponge Siphonochalina fortis, was evaluated inlaboratory and field trials. Toxicity and settlement assays were performed with the mussel Mytilus edulisplatensis, while the field trials were carried out by addition of the compound to experimental soluble-matrixpaints, which were then tested in the sea. The results obtained in this work show that 1 has a good antifoulingactivity and low toxicity, and the paints aditivated with 0,6 % Wt showed promisory performances in thefield trials at the sea. These results confirm the previous hypothesis that the few acetylated and lipophilic bileacid derivatives isolated from marine invertebrates may act as natural antifoulants. Compound 1 is a natural,biodegradable product that can be easily prepared from cholic acid, which in turn can be isolated in industrialscale from cattle bile. All these facts make cholic acid a good scaffold for the preparation of derivatives,which can be natural product-like, effective and sustainable antifouling additives for marine paints and otherapplications.

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