Isolation and Antifouling Activity of Azulene Derivatives from the Antarctic Gorgonian Acanthogorgia laxa

LAURA P. PATIÑO CANO; RODRIGO QUINTANA MANFREDI; MIRIAM PÉREZ; MÓNICA GARCÍA; GUILLERMO BLUSTEIN

Chemistry and Biodiversity

WILEY-V C H VERLAG GMBH

Año: 2018

1612-1872

Three azulenoid sesquiterpenes (1 ? 3) were isolated from the Antarctic gorgonian Acanthogorgia laxa collectedby bottom trawls at 343 m. Besides linderazulene (1), and the known ketolactone 2, a new brominated C16linderazulene derivative (3) was also identified. This compound has an extra carbon atom at C(7) of the linderazuleneframework. The antifouling activity of compounds 1 and 2 was assayed in the laboratory with Artemia salina larvae,and also in field tests, by incorporation in soluble-matrix experimental antifouling paints. The results obtained after a45 days field trial of the paints, showed that compounds 1 and 2 displayed good antifouling potencies against awide array of organisms. Compound 3, a benzylic bromide, was unstable and for this reason was not submitted tobioassays. Two known cembranolides: pukalide and epoxypukalide, were also identified as minor components of theextract.