INVESTIGADORES
ZENI Susana Noemi
artículos
Título:
MicroRNAs and bone cells
Autor/es:
BONANNO MARINA SOLEDAD; ZENI CORONEL MAGALÍ; SEIJO MARIANA; ZENI SUSANA N
Revista:
Actualizaciones en Osteologia
Editorial:
Asociacion Argentina de osteologia y metabolismo mineral
Referencias:
Lugar: Rosario; Año: 2021
ISSN:
1669-8975
Resumen:
MicroRNAs (miRNAs) are endogenous small noncoding RNA molecules (of approximately 15?25 nucleotides), which regulate gene expression of many biological functions, through the inhibition or degradation of the target messenger RNA. Bone homeostasis is maintained by a balance between osteoblastic bone formation and osteoclastic bone resorption. The overexpression or inhibition of specific miRNAs affects cell proliferation, differentiation and activity of osteoblast and osteoclast. This action is done by modulating the expression of different transcription factors and signaling molecules of the most knowledge pathways of osteoblastogenesis or osteoclastogenesis. This effect is able to modify the balance between bone formation and resorption, determining changes in bone homeostasis. The present review is an overview of a series of miRNAs involved in bone homeostasis. Deeping knowledge in the mechanisms by which miRNAs acts on bone may reveal potential uses in the future as new bone biomarkers or therapeutic agents for treating metabolic bone disorders, bone loss and bone diseases.
