Open-loop dynamic optimization for nonlinear multi-input systems. Application to recombinant protein production

PANTANO, MARIA NADIA; FERNANDEZ PUCHOL, MARIA CECILIA; ROSSOMANDO, FRANCISCO GUIDO; SCAGLIA, GUSTAVO J. E.

IEEE LATIN AMERICA TRANSACTIONS

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

Año: 2021 vol. 19 p. 1307 - 1314

1548-0992

This paper proposes a novel strategy for dynamic open-loop optimization of multivariable nonlinear systems. The methodology is based on the Fourier series and orthonormal polynomials for the control vector parameterization in a sequential direct solution approach. The advantages of this technique are that a few number of parameters is required for optimization and a smooth control profile is obtained. The proposed strategy is evaluated in the case study of recombinant protein production, that is a nonlinear system with two control actions, the substrate and inhibitor feed flow rate. The algorithms are tested through simulations and the results are compared with those published in the bibliography.