CINDEFI 05381
CENTRO DE INVESTIGACION Y DESARROLLO EN FERMENTACIONES INDUSTRIALES
Unidad Ejecutora - UE
artículos
Título:
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by Fimbriae-specific antibodies
Autor/es:
MARIA EUGENIA RODRIGUEZ; HELLWIG, S.; PEREZ VIDACOVIKS, M. L.; BERBERS, G.; WINKEL, JAN GJ VAN DE
Revista:
Fems Immunology and Medical Microbiology
Editorial:
Blackwell Publishing Ltd.
Referencias:
Lugar: Oxford; Año: 2006 vol. 46 p. 39 - 47
ISSN:
0928-8244
Resumen:
Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti- B. pertussis IgG or IgA fractions efficiently decreased attachment. This effect was found to be mainly mediated by fimbriae-specific antibodies. The strong agglutinating activity of anti-fimbriae antibodies seems to be involved in this phenomenon.
