Optimization of non-uniform oscillating gradient spin echo sequences for selective microstructure-size imaging

MILENA CAPIGLIONI; ANALIA ZWICK; GONZALO A. ALVAREZ

Proceedings of the International Society for Magnetic Resonance in Medicine

Wiley

Año: 2023 vol. 31

Diffusion-weighting imaging is a promising method for quantitative imaging of tissue microstructurefeatures that may identify early stages of pathologies. Non-uniform oscillating gradient spin-echo(NOGSE) sequences are a novel technique to study diffusion spectra and quantitatively characterizetissue. The sequence contrasts the signal between two modulating gradient frequencies to filter thesignal originating from molecules diffusion in specific restriction sizes. We determine the range ofcontrol parameters that maximizes NOGSE contrast for filtering the restriction sizes. We assess therestriction sizes that this sequence can filter with current technologies.