INVESTIGADORES
PEREZ Mariela Fernanda
artículos
Título:
Environmental changes modify the expression of Diazepam
Autor/es:
PEREZ MF, MAGLIO LE , MARCHESINI GR , MOLINA JC , RAMIREZ OA.
Revista:
BEHAVIOURAL BRAIN RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2002 vol. 136 p. 75 - 81
ISSN:
0166-4328
Resumen:
Early results from our laboratory have demonstrated a positive correlation between increased hippocampal synaptic plasticity and
development of tolerance to hypolocomotive effect of Diazepam (DZ). We have found recently, that pre-exposure to DZ
administration context impairs increase of hippocampal synaptic plasticity in conjunction with tolerance to DZ. These findings have
suggested, that the tolerance to DZ is context specific. Furthermore, the hippocampus can be critically involved in the behavioral
expression of conditioned tolerance to DZ. The results of the present investigation show that animals chronically treated with DZ
for 18 days exhibit withdrawal signs, evaluated as an increased anxiety in an elevated plus maze. These animals also show, a
facilitation in the threshold to induce long-term potentiation in the hippocampal formation. These phenomena have a strong
dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.ve demonstrated a positive correlation between increased hippocampal synaptic plasticity and
development of tolerance to hypolocomotive effect of Diazepam (DZ). We have found recently, that pre-exposure to DZ
administration context impairs increase of hippocampal synaptic plasticity in conjunction with tolerance to DZ. These findings have
suggested, that the tolerance to DZ is context specific. Furthermore, the hippocampus can be critically involved in the behavioral
expression of conditioned tolerance to DZ. The results of the present investigation show that animals chronically treated with DZ
for 18 days exhibit withdrawal signs, evaluated as an increased anxiety in an elevated plus maze. These animals also show, a
facilitation in the threshold to induce long-term potentiation in the hippocampal formation. These phenomena have a strong
dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.velopment of tolerance to hypolocomotive effect of Diazepam (DZ). We have found recently, that pre-exposure to DZ
administration context impairs increase of hippocampal synaptic plasticity in conjunction with tolerance to DZ. These findings have
suggested, that the tolerance to DZ is context specific. Furthermore, the hippocampus can be critically involved in the behavioral
expression of conditioned tolerance to DZ. The results of the present investigation show that animals chronically treated with DZ
for 18 days exhibit withdrawal signs, evaluated as an increased anxiety in an elevated plus maze. These animals also show, a
facilitation in the threshold to induce long-term potentiation in the hippocampal formation. These phenomena have a strong
dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.ve
suggested, that the tolerance to DZ is context specific. Furthermore, the hippocampus can be critically involved in the behavioral
expression of conditioned tolerance to DZ. The results of the present investigation show that animals chronically treated with DZ
for 18 days exhibit withdrawal signs, evaluated as an increased anxiety in an elevated plus maze. These animals also show, a
facilitation in the threshold to induce long-term potentiation in the hippocampal formation. These phenomena have a strong
dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.volved in the behavioral
expression of conditioned tolerance to DZ. The results of the present investigation show that animals chronically treated with DZ
for 18 days exhibit withdrawal signs, evaluated as an increased anxiety in an elevated plus maze. These animals also show, a
facilitation in the threshold to induce long-term potentiation in the hippocampal formation. These phenomena have a strong
dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.vestigation show that animals chronically treated with DZ
for 18 days exhibit withdrawal signs, evaluated as an increased anxiety in an elevated plus maze. These animals also show, a
facilitation in the threshold to induce long-term potentiation in the hippocampal formation. These phenomena have a strong
dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.valuated as an increased anxiety in an elevated plus maze. These animals also show, a
facilitation in the threshold to induce long-term potentiation in the hippocampal formation. These phenomena have a strong
dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.ve a strong
dependency on the drug administration context, since both are reversed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.versed after the introduction of some changes in the drug
administration environment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.vironment. Furthermore, the alteration of some environmental cues increased the locomotive activity in animals
that did not show anxiety as a withdrawal signs. We conclude that a common neural system could underlie the behavioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.vioral expression
of the conditioned tolerance and dependence on DZ. # 2002 Elsevier Science B.V. All rights reserved.# 2002 Elsevier Science B.V. All rights reserved.