INVESTIGADORES
APPIGNANESI gustavo Adrian
artículos
Título:
What size RNA loop holds bulk solvent?
Autor/es:
A. FERNÁNDEZ; G. A. APPIGNANESI; H. CENDRA
Revista:
CHEMICAL PHYSICS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 1995 vol. 242 p. 460 - 464
ISSN:
0009-2614
Resumen:
The loss in conformational entropy that results from the closure of a loop in a polymer chain has been derived in cases where the effects of discrete solvent structure inside the loop can be neglected. We show that a pronounced entropic contribution is encountered as the discrete clustering of solvent molecules inside the loop affects the conformations of the chain, forcing the orientation of individual residues. An algorithm for RNA structure prediction incorporating such effects is implemented and tested.
