INVESTIGADORES
GULTEMIRIAN Maria De lourdes
artículos
Título:
Insights on the evolution of Coronavirinae in general, and SARS-CoV-2 in particular, through innovative biocomputational resources
Autor/es:
DOS SANTOS DANIEL; REYNAGA MARIA CELINA; GONZÁLEZ JUAN CRUZ; FONTANARROSA GABRIELA; GULTEMIRIAN MARÍA DE LOURDES; NOVILLO AGUSTINA; ABDALA VIRGINIA
Revista:
PeerJ
Editorial:
Peer J
Referencias:
Año: 2022
ISSN:
2167-8359
Resumen:
The structural proteins of coronaviruses portray critical information to address issuesof classification, assembly constraints, and evolutionary pathways involving host shifts.We compiled 173 complete protein sequences from isolates belonging to the four generaof the subfamily Coronavirinae. We calculate a single matrix of viral distance as a linearcombination of protein distances. The minimum spanning tree (MST) connectingthe individuals captures the structure of their similarities. The MST re-capitulates theknown phylogeny of Coronovirinae. Hosts were mapped onto the MST and we founda non-trivial concordance between host phylogeny and viral proteomic distance. Wealso study the chimerism in our dataset through computational simulations. We foundevidence that structural units coming from loosely related hosts hardly give rise tofeasible chimeras in nature. This work offers a fresh way to analyze features of SARSCoV-2 and related viruses.
