Alzheimer's disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration

OLIVERA, EUGENIA; SÁEZ, ALBANY; CARNIGLIA, LILA; CARUSO, CARLA; LASAGA, MERCEDES; DURAND, DANIELA

NEURAL REGENERATION RESEARCH

SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES

Año: 2023 vol. 18 p. 1404 - 1410

1673-5374

In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration, we aimed at revisiting the infectious hypothesis of Alzheimer´s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration. We wondered how SARS-CoV-2 could be related to the amyloid-β cascade and how it could lead to the pathological hallmarks of the disease. We also predict a paradigm change in clinical medicine, which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer´s disease.