Intravesical therapy with Vinorelbine tartrate: antitumor activity in ortothopic murine cell carcinoma of the bladder.

BONFIL, RD, RUSSO, DM, SCHMILOVICH, AJ AND GARCÍA PALAZZO, IE.

JOURNAL OF UROLOGY

American Urological Association

Año: 1997 vol. 158 p. 912 - 915

0022-5347

Abstract Objectives: To ascertain intravesical vinorelbine tartrate (VNR) antitumor activity against MB-49, a murine transitional cell carcinoma of the bladder (TCC), in an in vivo setting. Materials and Methods: C57Bl/6J female mice were intravesically implanted with 5 x 104 MB-49 cells and treated locally with VNR. Tumor incidence and volume analyses, as well as survival studies were carried out. Results: Tumor incidence was significantly lower in VNR-treated mice (48%, n = 23) than in controls (84%, n = 19), as evaluated sixteen days after MB-49 orthotopic inoculation. Intravesical tumor volume was also significantly smaller in treated mice respect to controls (median [range]: 0.5 [0.4 to 61.8] mm.3 versus 47.7 [4.2 to 179.7] mm.3 respectively, p <0.001 Kruskal-Wallis test). Median survival duration of the animals treated with VNR was 68 [21 to 68] days, and was significantly greater (p = 0.01, Kruskal-Wallis test) than that of untreated controls (18 [16 to 20] days). Conclusion: Intravesical VNR treatment demonstrated an evident antitumor effect against the TCC model assayed. The results obtained suggest a potential use of VNR as intravesical treatment for superficial TCC following transurethral bladder tumor resection to prevent recurrence or retard tumor growth. Key Words: vinorelbine; bladder neoplasms; chemotherapy.