Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

SOSNIK, A; SEREMETA, KP

ADVANCES IN COLLOID AND INTERFACE SCIENCE.

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 223 p. 40 - 54

0001-8686

Spray-drying is a rapid, continuous, cost-effective, reproducible and scalable process for the production of dry powders from a fluid material by atomization through an atomizer into a hot drying gas medium, usually air. Often spray-drying is considered only a dehydration process, though it also can be used for the encapsulation of hydrophilic and hydrophobic active compounds within different carriers without substantial thermal degradation, even of heat-sensitive substances due to fast drying (seconds or milliseconds) and relatively short exposure time to heat. The solid particles obtained present relatively narrow size distribution at the submicron-to-micron scale. Generally, the yield% of spray-drying at laboratory scale with conventional spray-dryers is not optimal (20-70%) due to the loss of product in the walls of the drying chamber and the low capacity of the cyclone to separate fine particles (