INVESTIGADORES
ZENI Susana Noemi
artículos
Título:
Bone mass recovery of osteopenic-vitamin D insufficient rats from strontium ranelate treatment:Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 vs. D3)?
Autor/es:
GONZALES CHAVES M; MAROTTE C; PELLEGRINI G; PIGHIN A; DE LANDETA MC; FIMA LIFSHITZ; FRIEDMAN S; MANDALUNIS P; ZENI SN
Revista:
Journal of Musculoskeletal Research
Editorial:
JMER
Referencias:
Lugar: Atenas; Año: 2010 vol. 13 p. 95 - 108
ISSN:
0218-9577
Resumen:
It was investigated if vitamin D (vitD) status or source (D2 vs. D3) interferes with bone mass
recovery from strontium ranelate (SrRa) treatment of rats with vitD insufficiency and established
osteopenia. Osteopenic and vitD insufficient rats were divided in groups to complete a 105-day period.
1st experiment: they were fed diets that only varied in vitD (100 vs. 0 IU%) and/or SrRa (0 vs.
900mg/kg/day) content. A SHAM group received vit D throughout the experience. 2nd experiment:
rats were divided to receive vitD2 or vitD3 by diet and SrRa by gavages in a fasting state. Two SHAM
groups received vitD2 or vitD3 throughout the study. Results: Levels of 25OHD were reduced in groups
lacking dietary vitD (p<0.001). Independently of vitD status or source, SrRa did not affect body weight
gain or bone alkaline phosphatase levels; osteocalcin and C-terminal telopeptide of type I collagen
levels were reduced (p<0.05) and bone Sr content was increased (p<0.0001), although no
improvement in biomechanical parameters was observed; total skeleton bone mineral content and
proximal tibial bone mineral density were increased (p<0.05); there was a reduction in the trabecular
number and, an increase in the trabecular surface and bone volume without reaching SHAM levels.
Conclusion: This is the first study which examined SrRa effects in an osteopenic vitamin D-insufficient
experimental model. Under our experimental condition, SrRa increased bone Sr content independently
of vitD status or source, however no evidence of an anabolic or anti-fracture effect was found and only
a slight decrease in some bone resorption parameters were observed.