INVESTIGADORES
DE NICOLA Alejandro Federico
artículos
Título:
Short-term environmental enrichment enhances adult neurogenesis, vascular network and denditric complexity in the hippocampus of type I diabetic mice
Autor/es:
BEAUQUIS J.; ROIG P.; DE NICOLA A.F.; SARAVIA, FE
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Año: 2010 vol. 5 p. 1 - 12
ISSN:
1932-6203
Resumen:
Background
Several
brain disturbances have been described in association to type 1
diabetes in humans. In animal models, hippocampal pathological changes
were reported together with cognitive deficits. The exposure to a
variety of environmental stimuli during a certain period of time is able
to prevent brain alterations and to improve learning and memory in
conditions like stress, aging and neurodegenerative processes.
Methodology/Principal Findings
We
explored the modulation of hippocampal alterations in
streptozotocin-induced type 1 diabetic mice by environmental enrichment.
In diabetic mice housed in standard conditions we found a reduction of
adult neurogenesis in the dentate gyrus, decreased dendritic complexity
in CA1 neurons and a smaller vascular fractional area in the dentate
gyrus, compared with control animals in the same housing condition. A
short exposure -10 days- to an enriched environment was able to enhance
proliferation, survival and dendritic arborization of newborn neurons,
to recover dendritic tree length and spine density of pyramidal CA1
neurons and to increase the vascular network of the dentate gyrus in
diabetic animals.
Conclusions/Significance
The
environmental complexity seems to constitute a strong stimulator
competent to rescue the diabetic brain from neurodegenerative
progression.
Citation: Beauqu