Effect of gangliosides in the autoimmune response induced by liposome-associated antigens

CORREA, S.G.; RIVERO, V.E.; YRANZO-VOLONTE, N.; ROMERO-PIFFIGUER, M.; FERRO, M.E.; RIERA, C.M.

AUTOIMMUNITY

TAYLOR & FRANCIS LTD

Año: 1993 vol. 15 p. 195 - 200

0891-6934

A model of autoimmunity to rat male accessory glands (RAG) was recently developed by intraperitoneal administration of three doses of native RAG associated with liposomes. In this work we analysed the effects of gangliosides in the cellular response to RAG when they were intraperitoneally administrated prior to the second dose of liposome-associated RAG. Results show that the ganglioside treatment could modify an established DTH response. Also, gangliosides markedly reduced the number of Ia antigen-positive peritoneal exudated cells (PEC). However, they modified neither the processing of liposomes through PEC nor their viability. Moreover, we obtained cellular response by transferring PEC from immunized donors into naive receptors. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.