The translational approach to liver transplantation

GONDOLESI, GABRIEL E.; GENTILINI, M. VIRGINIA; BENITEZ, P. CONSTANZA ARRIOLA

ANNALS OF HEPATOLOGY

MEXICAN ASSOC HEPATOLOGY

Año: 2022 vol. 27

1665-2681

Liver transplantation has proved to be a successful life-saving treatment for end-stage liver diseases. Yet, despite the remarkable progress made since the first successful human liver transplant, many open questions still need to be addressed. The solution for a number of current issues requires the implementation of adequate research programs as part of the clinical agenda. However, the process of bringing basic science knowledge into clinical practice remains a challenge. The need to potentiate the development of innovative discoveries capable of improving human health has opened the doors to new possibilities for experts and programs. Salient among them is the opportunity to establish a multi-step process for transforming observations in the clinic, laboratories and the community into interventions that enhance people's lives through diagnostic, therapeutic, procedural, device and behavioral changes that have been designated as translational research and science. This type of research has found transplantation to be a fertile ground for development; transplantation and translational science call for and encourage multidisciplinary collaborations to identify and support the adoption of more effective medical practices for the benefit of patients requiring novel and unique therapeutic approaches