The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology

FALCINELLI, EMANUELA; ALESSI, MARIE-CHRISTINE; SANTORO, CRISTINA; FONTANA, PIERRE; KANNAN, MEGANATHAN; FALAISE, CÉLINE; ZANINETTI, CARLO; ZUNIGA, PAMELA; HAYWARD, CATHERINE; MAZZUCCONI, MARIA GABRIELLA; HENSKENS, YVONNE; GKALEA, VASILIKI; ZIEGER, BARBARA; GIORDANO, PAOLA; ABID, MADIHA; RUSSO, ALEXANDRA; HARRISON, PAUL; LORDKIPANIDZÉ, MARIE; BURY, LOREDANA; BORHANY, MUNIRA; CID, ANA ROSA; DE CANDIA, ERICA; JURK, KERSTIN; GUGLIELMINI, GIUSEPPE; FIORE, MATHIEU; MIYAZAKI, KOJI; CASONATO, ALESSANDRA; JAMES, PAULA; NAPOLITANO, MARIASANTA; FEDOR, MARIAN; BARCELLA, LUCA; PORRI, CLAUDIA; GLEMBOTSKY, ANA C.; DECKMYN, HANS; MEZZANO, DIEGO; GRESELE, PAOLO; PECCI, ALESSANDRO; HELLER, PAULA G.; ORSINI, SARA; PODDA, GIANMARCO; CASTAMAN, GIANCARLO; NORIS, PATRIZIA; TOSETTO, ALBERTO; DUPUIS, ARNAUD; GRANDONE, ELVIRA; FABRIS, FABRIZIO; CURNOW, JENNIFER; LAMBERT, MICHELE P.; COSMI, BENILDE; MELAZZINI, FEDERICA; FERRARA, GRAZIA; FRELINGER, ANDREW L.; MUMFORD, ANDREW D

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

WILEY-BLACKWELL PUBLISHING, INC

Año: 2021 vol. 19 p. 1364 - 1371

1538-7933

Background: The ISTH Bleeding Assessment Tool (ISTH-BAT) has been validated for clinical screening of suspected von Willebrand disease (VWD) and for bleeding prediction. Recently it has been validated for subjects with inherited platelet disorders (IPD) (BAT-VAL study). Objectives: To determine whether the ISTH-BAT bleeding score (BS) predicts subsequent bleeding events requiring treatment in IPD patients. Methods: Patients with IPD, type 1 VWD (VWD-1) and age- and sex-matched healthy controls enrolled in the BAT-VAL study were prospectively followed-up for 2 years and bleeding episodes requiring treatment were recorded. Results: Of the 1098 subjects initially enrolled, 955 were followed-up and 124 suffered hemorrhages during follow-up, 60% of whom had inherited platelet function disorders (IPFD). Total number of events was significantly higher in IPFD (n = 235) than VWD-1 (n = 52) or inherited thrombocytopenia (IT; n = 20). Events requiring transfusions were 66% in IPFD, 5.7% in VWD-1, and 3% in IT. Baseline BS was significantly higher in IPFD patients with a bleeding event at follow-up than in those without (p