Antimicrobial metabolites produced by an intertidal Acremonium furcatum.

GALLARDO, G.; BUTLER, M.; GALLO, M.L.; RODRÍGUEZ, M.A.; EBERLIN, M.N.; CABRERA, G.M.

PHYTOCHEMISTRY

Elsevier

Lugar: Cambridge; Año: 2006 vol. 67 p. 2403 - 2410

0031-9422

In a screening for antimicrobial metabolites, amides of D-allo- and L-isoleucine derivatives were isolated from the culture of a marine strain of Acremonium furcatum. Structural elucidation of these compounds was performed by analysis of spectroscopic data and con- firmed by synthesis. All of the compounds, natural and synthetic intermediates, were bioassayed against bacteria and phytopathogenic fungi, with many showing remarkable antifungal activities.