INVESTIGADORES
BOCCACCIO Graciela Lidia
artículos
Título:
Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse
Autor/es:
MALENA PASCUAL,; LUCIANA LUCHELLI; MARTÍN HABIF; BOCCACCIO, GRACIELA L
Revista:
Communicative & Integrative Biology
Editorial:
Landes Bioscience
Referencias:
Año: 2012 vol. 5 p. 388 - 392
ISSN:
1942-0889
Resumen:
The regulated synthesis of
specific proteins at the synapse is important for neuron plasticity, and several
localized mRNAs are translated upon specific stimulus. Repression of mRNA translation
is linked to the formation of mRNA-silencing foci, including Processing Bodies (PBs) and Stress Granules (SGs),
which are macromolecular aggregates that harbor silenced messengers and
associated proteins. In a recent work, we identified a type of mRNA-silencing foci unique to neurons, termed S-foci, that contain the
post-transcriptional regulator Smaug1/SAMD4. Upon specific synaptic
stimulation, the S-foci dissolve and
release mRNAs to allow their translation, paralleling the cycling of mRNAs
between PBs and polysomes in other cellular contexts. Smaug 1 and other
proteins involved in mRNA regulation in neurons contain aggregation domains
distinct from their RNA binding motifs, and we speculate that self-aggregation helps
silencing and transport, which occurs in granules. In addition to S-foci and PBs, other foci formed by distinct RNA binding proteins, including TDP-43 and
FMRP among others, respond dynamically to distinct synaptic stimuli. We propose
the collective name of synaptic activity-regulated mRNA silencing (SyAS) foci for these RNP aggregates that
selectively respond to distinct stimulation patterns and contribute to the fine
tuning of local protein synthesis at the synapse.