INVESTIGADORES
CAPANI Francisco
artículos
Título:
Moderate and Severe Perinatal Asphyxia
Autor/es:
GALEANO P, ROMERO JI, LUQUE-ROJAS MJ, SUÁREZ J, HOLUBIEC MI, BISAGNO V, SANTÍN LJ, DE FONSECA FR, CAPANI F, BLANCO E.
Revista:
SYNAPSE
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2013
ISSN:
0887-4476
Resumen:
Perinatal asphyxia (PA) increases the likelihood of suffering from dopamine-
related disorders, such as ADHD and schizophrenia. Since dopaminergic
transmission plays a major role in cocaine sensitization, the purpose of this study was
to determine whether PA could be associated with altered behavioral sensitization to
cocaine. To this end, adult rats born vaginally (CTL), by caesarean section (C1), or by
C1 with 15 min (PA15, moderate PA) or 19 min (PA19, severe PA) of global anoxia
were repeatedly administered with cocaine (i.p., 15 mg/kg) and then challenged with
cocaine (i.p., 15 mg/kg) after a 5-day withdrawal period. In addition, c-Fos, FosB/
DFosB, DAT, and TH expression were assessed in dorsal (CPu) and ventral (NAcc)
striatum. Results indicated that PA15 rats exhibited an increased locomotor sensitization
to cocaine, while PA19 rats displayed an abnormal acquisition of locomotor sensitization
and did not express a sensitized response to cocaine. c-Fos expression in NAcc,
but not in CPu, was associated with these alterations in cocaine sensitization. FosB/
DFosB expression was increased in all groups and regions after repeated cocaine
administration, although it reached lower expression levels in PA19 rats. In CTL, C1,
and PA15, but not in PA19 rats, the expression of TH in NAcc was reduced in groups
repeatedly treated with cocaine, independently of the challenge test. Furthermore,
this reduction was more pronounced in PA15 rats. DAT expression remained unaltered
in all groups and regions studied. These results suggest that moderate PA may
increase the vulnerability to drug abuse and in particular to cocaine addiction. Synapse
00:000000, 2013. VC 2013 Wiley Periodicals, Inc.