INVESTIGADORES
CAPANI Francisco
artículos
Título:
Effects of natural antioxidants in neurodegenerative disease
Autor/es:
SONIA LUZ ALBARRACIN, BEN STAB, ZULMA CASAS, JHON JAIRO SUTACHAN ISMAEL SAMUDIO, JANNETH GONZALEZ, LUIS GONZALO, FRANCISCO CAPANI,
Revista:
NUTRITIONAL NEUROSCIENCE
Editorial:
MANEY PUBLISHING
Referencias:
Lugar: London; Año: 2012 vol. 15 p. 1 - 19
ISSN:
1028-415X
Resumen:
Polyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits,
vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite
their abundance, investigations into the benefits of polyphenols in human health have only recently begun.
Phenolic compounds have received increasing interest because of numerous epidemiological studies.
These studies have suggested associations between the consumption of polyphenol-rich aliments and the
prevention of chronic diseases, such as cancer, cardiovascular diseases, and neurodegenerative diseases.
More specifically, in the last 10 years literature on the neuroprotective effects of a polyphenol-rich diet has
grown considerably. It has been demonstrated, in various cell culture and animal models, that these
metabolites are able to protect neuronal cells by attenuating oxidative stress and damage. However, it
remains unclear as to how these compounds reach the brain, what concentrations are necessary, and
what biologically active forms are needed to exert beneficial effects. Therefore, further research is needed
to identify the molecular pathways and intracellular targets responsible for polyphenols neuroprotective
effects. The aim of this paper is to present various well-known dietary polyphenols and their mechanisms
of neuroprotection with an emphasis on Alzheimers disease, Parkinsons disease, and amyotrophic lateral
sclerosiss neuroprotective
effects. The aim of this paper is to present various well-known dietary polyphenols and their mechanisms
of neuroprotection with an emphasis on Alzheimers disease, Parkinsons disease, and amyotrophic lateral
sclerosiss disease, Parkinsons disease, and amyotrophic lateral
sclerosis