INVESTIGADORES
CAPANI Francisco
artículos
Título:
Novel interactions of GRP78: UPR and estrogen responses in the brain.
Autor/es:
MARCO FIDEL AVILA1, RICARDO CABEZAS1, DANIEL TORRENTE1, JANNETH GONZALEZ1, LUDIS MORALES1,LISANDRO ALVAREZ2, FRANCISCO CAPANI AND GEORGE E. BARRETO1
Revista:
CELL BIOLOGY INTERNATIONAL
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2013 p. 522 - 532
ISSN:
1065-6995
Resumen:
Glucose-regulated protein 78 (GRP78; 78 kDa) belongs to a group of highly conserved heat shock proteins (Hsp) with
important functions at the cellular level. The emerging interest for GRP78 relies on its different functions, both in normal and
pathological circumstances. GRP78 regulates intracellular calcium, protein shaping, endoplasmic reticulum (ER) stress and cell
survival by an immediate response to insults, and that its expression may also be regulated by estrogens. Although these roles are
well explored, the mechanisms by which GRP78 induces these changes are not completely understood. In this review, we
highlight various aspects related to the GRP78 functioning in cellular protection and repair in response to ER stress and
unfolded protein response by the regulation of intracellular Ca2þ and other mechanisms. In this respect, the novel interactions
between GRP78 and estrogens, such as estradiol and others, are analyzed in the context of the central nervous system (CNS).We
also discuss the importance of GRP78 and estrogens in brain diseases including ischemia, Alzheimer´s and Huntington´s
disorders. Finally, the main protective mechanisms of GRP78 and estrogens during ER dysfunction in the brain are described,
and the prospective roles of GRP78 in therapeutic processes.