INVESTIGADORES
CAPANI Francisco
artículos
Título:
Early changes in the synapses of the neostriatum induced by perinatal asphyxia
Autor/es:
M. GRIMALDI1, I. ROMER1, M. T. GONZÁLEZ DE APODACA1, L. ITURBE1, I. D. CATANIA1,
Revista:
NUTRITIONAL NEUROSCIENCE
Editorial:
MANEY PUBLISHING
Referencias:
Lugar: London; Año: 2012 vol. 15 p. 103 - 110
ISSN:
1028-415X
Resumen:
Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different
long-term neurological diseases. In previous work we have observed at 6 months post-synaptic densities
(PSDs) alterations compatible with neurodegeneration highly correlated with the increment in the
ubiquitination. Although alterations in the synaptic organization and function have been related with
neuronal death after hypoxia, little is known about the synaptic changes in young animals exposed to PA.
The main aim of this work is to study the PSDs changes in striatum of 30-day-old rats subjected to PA.
Using two-dimensional electron microscopic analyses of synapses staining with ethanolic
phosphotungstic acid we observed an increment of PSD thickness in severe hypoxic rats. These data are
consistent with the western blot analysis that showed an increment in ubiquitination levels in the synapses
of severe hypoxic rat. We did observe any alterations neither in synaptic structure nor in ubiquitinization in
mild asphyctic rats. These data suggest that hypoxia might cause early misfolding and aggregation of
synaptic proteins in severe anoxic animas that could induce long-term neurodegeneration.