INVESTIGADORES
CAPANI Francisco
artículos
Título:
An early treatment with 17-ß-estradiol is neuroprotective against the long-term effects of neonatal ionizing radiation exposure
Autor/es:
CACERES, L.G.; URAN S; ZORRILLA ZUBILETE; ROMERO JI; CAPANI F; GUELMAN L
Revista:
JOURNAL OF NEUROCHEMISTRY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2011
ISSN:
0022-3042
Resumen:
Abstract
Ionizing radiations can induce oxidative stress on target tissues,
acting mainly through reactive oxygen species (ROS).
The aim of this work was to investigate if 17-b-estradiol (bE)
was able to prevent hippocampal-related behavioral and biochemical
changes induced by neonatal ionizing radiation
exposure and to elucidate a potential neuroprotective mechanism.
Male Wistar rats were irradiated with 5 Gy of X-rays
between 24 and 48 h after birth. A subset of rats was subcutaneously
administered with successive injections of bE or
17-a-estradiol (aE), prior and after irradiation. Rats were
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
17-a-estradiol (aE), prior and after irradiation. Rats were
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was able to prevent hippocampal-related behavioral and biochemical
changes induced by neonatal ionizing radiation
exposure and to elucidate a potential neuroprotective mechanism.
Male Wistar rats were irradiated with 5 Gy of X-rays
between 24 and 48 h after birth. A subset of rats was subcutaneously
administered with successive injections of bE or
17-a-estradiol (aE), prior and after irradiation. Rats were
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
17-a-estradiol (aE), prior and after irradiation. Rats were
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
b-estradiol (bE)
was able to prevent hippocampal-related behavioral and biochemical
changes induced by neonatal ionizing radiation
exposure and to elucidate a potential neuroprotective mechanism.
Male Wistar rats were irradiated with 5 Gy of X-rays
between 24 and 48 h after birth. A subset of rats was subcutaneously
administered with successive injections of bE or
17-a-estradiol (aE), prior and after irradiation. Rats were
subjected to different behavioral tasks to evaluate habituation
and associative memory as well as anxiety levels. Hippocampal
ROS levels and protein kinase C (PKC) activity were
also assessed. Results show that although bE was unable to
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in bE-treated irradiated rats approached
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
control values. In addition, aE administered to irradiated animals
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
was effective in preventing radiation-induced alterations.
In conclusion, bE was able to counteract behavioral and biochemical
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
changes induced in irradiated animals, probably
acting through an antioxidant mechanism.
prevent radiation-induced hippocampal PKC activity changes,
most behavioral abnormalities were reversed. Moreover, hippocampal
ROS levels in b