Editorial: Glyphosate Herbicide as Endocrine Disruptor and Probable Human Carcinogen: Current Knowledge and Future Direction

ROSSETTI, MARÍA FLORENCIA; VARAYOUD, JORGELINA; DALLEGRAVE, ELIANE; LORENZ, VIRGINIA; MILESI, MARÍA MERCEDES

Frontiers in Endocrinology

Frontiers Media S.A.

Año: 2021 vol. 12 p. 772911 - 772911

1664-2392

Glyphosate-based herbicides (GBHs) are the pesticides most globally used and the rate ofusage doesnotappear to slow. Although farmers, applicators and their families are the most susceptible population,some biomonitoring studies are indicating that glyphosate and aminomethylphosphonic acid (AMPA),its main metabolite, are found in biologicalfluids in populations from non-agricultural contexts (1,2).This is a real concern because the extent of the population potentially exposed to glyphosate herbicide isgreater than we think and the consequences become more difficult to restrain.In the current scenario, this Research Topic aims to revise, analyze and compile the state of theart of the two most controversial issues about the herbicide glyphosate: its potential as an endocrine-disrupting compound and as a probable human carcinogen. The present Research Topic includesdifferent kinds of articles: an original article (Gorga et al.), two reviews (Milesi et al.andRomano etal.) and three mini-reviews (Anderson et al.,Rodrı́guez et al.andRossetti et al.). These articlesdescribe different models of studies and possible targets of action of glyphosate herbicide which areclosely related with female and male reproduction, reproductive outcomes, hormonal balance andthe epigenome addressed by specialists in theirfields.