Delayed-type hypersensitivity and humoral immunity modulation by dietary lipids in a murine model of pulmonary tumorigenesis induced by urethan

PIEGARI, M; SALVADOR, AF; MUÑOZ, SE; VALENTICH, MA; EYNARD, AR

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Urban and Fisher. Elsevier

Año: 2000 vol. 53 p. 1 - 6

0940-2993

Mice fed on semi synthetic formulas containing 15% of corn oil (CO), cod fish liver oil (FO), oleic acid (O) or a mixture of 46% of palmitic and 507o of stearic acids (PS) were treated with urethane during 18 weeks for lung tumor induction. Delayed-type hypersensitivity (DTH) assay, hemagglutination assay and the amount of lung nodes  (Alveolar adenocarcinomas) were recorded. Results showed significantly greater  DTH in CO and FO with respect to O and PS feeding mice; the two last ones induced an essential fatty acid (EFA) deficiency (EFAD). In the O lot there was a non-significant diminution of the humoral response. EFAD animals exhibited a tendency to increase number of lung nodes in relation to CO and FO lots. Splenornegalia was recorded in FO lot. Confront between spleen weight and DTH showed a 72% correlation, suggesting an increase in cellular immunity as increasing instauration. It may be concluded that in this suitable model of tumorigenesis the manipulation of dietary lipids may be a strategy to modify the immune system response.