INVESTIGADORES
RIVAROLA Maria Angelica
artículos
Título:
EARLY MATERNAL SEPARATION AND CHRONIC
Autor/es:
RIVAROLA M. A.; DALMASSO C.; VALDEZ DJ; VIVAS LM; SUÁREZ M.M.
Revista:
THE INTERNATIONAL JOURNAL OF NEUROSCIENCE.
Editorial:
Informa Healthcare
Referencias:
Año: 2008 vol. 118 p. 735 - 748
ISSN:
0020-7454
Resumen:
The present study examined the participation of the anterodorsal thalamic nuclei
(ADTN) in mediating the long-term effects of early maternal separation on the
stress/hypothalamic-pituitary-adrenal axis response of adult animals. The study
measured Fos and glucocorticoid receptor immunoreactivity (GR-ir) in the ADTN
of maternally separated female rats subsequently exposed to variable chronic stress.
Maternal separation increased the number of neurons immunoreactive to Fos in the
ADTN of chronically stressed adult rats. GR-ir was absent in the ADTN. Linking
these results with previous endocrine evidence led the authors to propose a dual
role of these nuclei. Maternal separation and chronic stress enhance the neuronal
activity of the ADTN, nevertheless it is not regulated, at least directly, via GR.