INVESTIGADORES
CONTIN Maria Ana
artículos
Título:
INNER RETINAL CIRCADIAN CLOCKS AND NON-VISUAL PHOTORECEPTORS: NOVEL PLAYERS
Autor/es:
MARIO E. GUIDO; EDUARDO GARBARINO-PICO; MARIA ANA CONTIN; DIEGO J. VALDEZ; PAULA S. NIETO; DANIELA M. VERRA; VICTORIA A. ACOSTA RODRIGUEZ; NURIA DE ZAVALÍA; RUTH E. ROSENSTEIN
Revista:
PROGRESS IN NEUROBIOLOGY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2010 vol. 92 p. 484 - 504
ISSN:
0301-0082
Resumen:
Daily and annual changes in ambient illumination serve as specific stimuli that associate
light with time and regulate the physiology of the organism through the eye. The eye acts as a dual
sense organ linking light and vision, and detecting light that provides specific stimuli for nonclassical
photoreceptors located in the inner retina. These photoreceptors convey information to the
master circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN). Responsible for
sensing the light that regulates several non-visual functions (i.e. behavior, pupil reflex, sleep, and
pineal melatonin production), the retina plays a key role in the temporal symphony orchestra
playing the musical score of life: it is intrinsically rhythmic in its physiological and metabolic
activities. We discuss here recent evidence in support of the hypothesis that retinal oscillators
distributed over different cell populations may act as clocks, inducing changes in the visual and
circadian system according to the time of the day. Significant progress has recently been made in
identifying photoreceptors/photopigments localized in retinal ganglion cells (RGCs) that set
circadian rhythms and modulate non-visual functions. Autonomous retinal and brain oscillators
could have a more complex organization than previously recognized, involving a network of ?RGC
clock/SCN clock cross-talkE. The convergence of oscillatory and photoreceptive capacities of retinal
cells could deeply impact on the circadian system, which in turn may be severely impaired in
different retinal pathologies. The aim of this review is to discuss the state of the art on inner retinal
cell involvement in the light and temporal regulation of health and disease.
cells could deeply impact on the circadian system, which in turn may be severely impaired in
different retinal pathologies. The aim of this review is to discuss the state of the art on inner retinal
cell involvement in the light and temporal regulation of health and disease.
cells could deeply impact on the circadian system, which in turn may be severely impaired in
different retinal pathologies. The aim of this review is to discuss the state of the art on inner retinal
cell involvement in the light and temporal regulation of health and disease.
cells could deeply impact on the circadian system, which in turn may be severely impaired in
different retinal pathologies. The aim of this review is to discuss the state of the art on inner retinal
cell involvement in the light and temporal regulation of health and disease.
cells could deeply impact on the circadian system, which in turn may be severely impaired in
different retinal pathologies. The aim of this review is to discuss the state of the art on inner retinal
cell involvement in the light and temporal regulation of health and disease.
E. The convergence of oscillatory and photoreceptive capacities of retinal
cells could deeply impact on the circadian system, which in turn may be severely impaired in
different retinal pathologies. The aim of this review is to discuss the state of the art on inner retinal
cell involvement in the light and temporal regulation of health and disease.