A Systematic Review About the Contribution of The Genus Tessaria (Asteraceae) To Cancer Study and Treatment

SOSA LOCHEDINO, A; HAPON MB; GAMARRA LUQUES CD,

UNICIENCIA

EUNA

Lugar: Heredia; Año: 2022

1413-5418

Belonging to the Asteraceae family, Tessaria (Ruiz & Pavon, 1753) is a genus of shrubs or small trees distributedin various habitats located from Argentina to the southwestern United States of America. The taxa arecomposed of five confirmed species, which have been previously reported for their ethnopharmacologicaluses as hypocholesterolemiant, hypoglycemic, antitussive, anti-inflammatory, anticancer, and abortifacientagent; it also has been used in hepatic, renal, pulmonary, and rheumatic diseases. Up to the present, T.absinthioides, T. ambigua, T. dodoneifolia, T. fastigiata and T. integrifolia have been chemically analyzed.While decoctions, infusions, methanolic, and hydromethanolic extracts are the most studied botanicalcompounds, its most recognized phytochemical constituents are caffeoylquinic acid, eupatorin, naringenin,protocatechuic, and quercetin. Scientifically, several biomedical properties such as virucidal, antibacterial,leishmanicidal, insecticidal, gastroprotective, antiasthmatic, hypoglycemic, and antiatherogenic wereattributed to the genus. Concerning oncologic research, the chemicals produced by Tessaria have antitumoractivities interfering with carcinogenesis, cell proliferation, metastasis, and angiogenesis. In addition, thenatural extracts obtained from Tessaria species have biological activities closely related to cancer, actingas antioxidants and anti-inflammatories. In particular, it has been reported that T. absinthioides resultedcytotoxic against several cancer cell lines and acts as an antitumoral compound in murine models. Due tothe aforementioned antecedents, the Tessaria species are considered undervalued within the oncologicalfield; the goal of the current systematic review is to summarize the information available on the genus,relevant for cancer research and treatment.