99mTc-Ciprofloxacin Imaging: Still an Unsettled Issue?

PORTILLO, MARIANO; BERTELLI MENDOZA, ANDREA; TESAN, FIORELLA; NOTO LLANA M; ZUBILLAGA, MARCELA; SORDELLI, DANIEL; GOMEZ, MARISA; SALGUEIRO, JIMENA

International Journal of Nuclear Medicine Research

Cosmos Scholars Publishing House

Año: 2016

The objective of this work consisted in the assessment of 99mTc-ciprofloxacin imaging performance as adiagnostic tool in an experimental rat model of osteomyelitis. Bone (tibia) infection was induced in adult rats byinoculation of a suspension containing S. aureus suspended in fibrin glue. In vivo studies by means of small animalimaging were conducted using a gamma camera. The study shows the correlation between 99mTc-ciprofloxacin positiveimages with bacterial bone count but also with histopathological findings in an osteomyelitis animal model, highlightingits potential as a tool in preclinical research and the accomplishment of 3Rs concept regarding welfare of laboratoryanimals. 99mTc-MDP scintigraphy, failed to show these correlations and therefore it may be proposed as acomplementary method to diagnose and follow up the bone physiopathology in this animal model. Future perspectives ofsmall animal imaging in order to potentiate osteomyelitis basic research will derive from numerous research works, and99mTc-ciprofloxacin may still be a candidate for infectious diagnose and follow-up as demonstrated in this study.