INVESTIGADORES
ULLOA DE LA SERNA Rita Maria
artículos
Título:
Characterization of Neurospora crassa cyclic AMP Phosphodiesterase activated by Calmodulin
Autor/es:
TÉLLEZ-IÑÓN MT; ULLOA RM; GLIKIN GC; TORRES HN
Revista:
BIOCHEMICAL JOURNAL
Editorial:
Portland Press
Referencias:
Año: 1985 vol. 232 p. 425 - 430
ISSN:
0264-6021
Resumen:
Activation of cyclic AMP phosphodiesterase I by brain or Neurospora calmodulin was studied. The stimulation required micromolar concentrations of Ca2+, and it was observed at cyclic AMP concentrations between 0.1 and 500 ,UM. Activation was blocked by EDTAand some neuroleptic drugs such as chlorpromazine and fluphenazine. These drugs inhibit the elongation of N. crassa wild-type aerial hyphae. These results reinforce the evidence towards the recognition of Ca2+-calmodulin as one of the systems controlling cyclic nucleotide concentrations in Neurospora.AMP phosphodiesterase I by brain or Neurospora calmodulin was studied. The stimulation required micromolar concentrations of Ca2+, and it was observed at cyclic AMP concentrations between 0.1 and 500 ,UM. Activation was blocked by EDTAand some neuroleptic drugs such as chlorpromazine and fluphenazine. These drugs inhibit the elongation of N. crassa wild-type aerial hyphae. These results reinforce the evidence towards the recognition of Ca2+-calmodulin as one of the systems controlling cyclic nucleotide concentrations in Neurospora.
