Lesiones inducidas por concentraciones subletales de plomo en Rhamdia quelen

VIGLIANO, F.A.; MUÑOZ, L.; LÓPEZ, P.A.; WEBER, P.; BALDISSEROTTO, B.

Lavras

Congreso; III Conferencia Latinoamericana sobre Cultivo de Peces Nativos; 2011

Universidade Federal de Lavras

Entre lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> contaminante<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> que pueden e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tar pre<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ente<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> en el medio ambiente acuático, el plomo adquiere e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>pecial relevancia debido a la gran cantidad de po<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ible<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> fuente<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de contaminación de origen indu<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>trial y <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>u reconocido impacto en la <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>alud pública. El bagre <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>udamericano (Rhamdia quelen) e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> una e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>pecie bentónica ampliamente di<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tribuida en Sudamérica que por <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>u<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hábito<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> alimentario<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> re<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ulta una e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>pecie idónea como centinela en e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tudio<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de monitoreo de contaminación acuática. El objetivo de e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>te trabajo fue de<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>cribir la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> le<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ione<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> a micro<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>copía óptica inducida<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> por la expo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ición a do<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>i<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ubletale<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de plomo en di<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tinto<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> órgano<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de juvenile<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de R. quelen. Previo al en<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ayo lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> pece<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> fueron aclimatado<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> durante una <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>emana en tanque<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de 250 L con circulación cerrada y aireación continua, y alimentado<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> diariamente con ración comercial ha<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ta 24 hora<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> ante<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> del inicio del experimento. Se empleó un grupo control (n=10) <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>in expo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ición a plomo y un grupo de tratamiento (n=32) expue<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>to a una do<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>i<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ubletal de 44 mg L-1 de Pb (NO3)2 (25% de la CL50 determinada en un en<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ayo previo). Durante el experimento el agua pre<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>entó una temperatura de 19 °C, un pH de 6,5 y una dureza de 20 mg L-1 de CaCO3 en promedio. A la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> 24, 48, 72 y 96 hora<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> po<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>texpo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ición (hpe) al plomo, <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e procedió a la eutana<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ia y necrop<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ia <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>i<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>temática de ocho pece<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> del grupo tratamiento y <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e extrajeron mue<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tra<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de branquia<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>, riñón, bazo, encéfalo, corazón, hígado, inte<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tino a<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>cendente, de<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>cendente, convoluto y recto, la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> cuale<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e fijaron en líquido de Bouin y proce<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>aron para <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>u inclu<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ión en parafina. El mi<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>mo procedimiento <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e realizó al inicio del experimento para lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> pece<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> del grupo control. Lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> bloque<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de parafina fueron cortado<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> con un micrótomo convencional y lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> corte<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de 3-5 µm de e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>pe<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>or fueron teñido<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> con hematoxilina y eo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ina. En branquia<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> a la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> 24 hpe <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e ob<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ervó la mayor incidencia de edema laminillar y de<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>camación epitelial la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> cuále<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>cendieron a medida que aumentaron la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hpe. El hallazgo má<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> frecuente a la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> 24 hpe fue la necro<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>i<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> epitelial de laminilla<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> ob<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ervada en el 90% de lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> individuo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> mue<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>treado<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> para luego di<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>minuir <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>u ocurrencia hacia el final del experimento. Por el contrario, la hipertrofia de célula<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> reve<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>timiento, la hiperpla<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ia epitelial y la fu<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ión laminillar <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>i bien e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tuvieron pre<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ente<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> al inicio del experimento aumentaron <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>u incidencia con el incremento de la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hpe. En riñón <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e ob<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ervó degeneración turbia y necro<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>i<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de célula<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> tubulare<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> con pre<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>encia de célula<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>camada<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> en lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> túbulo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> colectore<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>. La <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>everidad y exten<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ión de la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> le<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ione<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> aumentaron en relación a la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hpe. En bazo <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e ob<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ervó una depleción linfática que <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e incrementó con la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hpe y una di<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tribución aleatoria de linfocito<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>. En el hígado <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e ob<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ervó una conge<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tión marcada y necro<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>i<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> oca<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ional de hepatocito<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>. La<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> modificacione<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> má<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> frecuente<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> que aumentaron con la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hpe fueron la reducción de la cantidad de vacuola<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> lipídica<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> y el tamaño de lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hepatocito<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>. En lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> órgano<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> del tubo dige<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tivo, la le<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ión má<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> frecuente fue el de<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>prendimiento del epitelio de ab<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>orción de la lámina propia, exi<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tiendo un aumento en la incidencia de e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>te hallazgo en relación con la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hpe al contaminante, en particular en el inte<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>tino a<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>cendente. No <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e ob<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ervaron le<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ione<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ignificativa<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> en corazón y cerebro. La mayoría de la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> le<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ione<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>crita<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>on compatible<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> con la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> reportada<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> para otro<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> metale<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> pe<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ado<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> en pece<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>. El incremento en la <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>everidad y exten<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ión de la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> le<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ione<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> ob<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ervada<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> en branquia<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> e hígado en relación directa a la<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> hpe al plomo <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e relacionan con re<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ultado<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> de trabajo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> previo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> del grupo en lo<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> que <<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>e determinó la bioacumulación de e<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>te metal pe<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>ado en dicho<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan> órgano<<span class="keyword">sspan>pan cla<span class="keyword">sspan><span class="keyword">sspan>="keyword"><span class="keyword">sspan>span class="keyword">sspan>pan>.