First description of an olfactory neuroblastoma in goldfish Carassius auratus L.: a case report

VIGLIANO, F.A.; MARCACCINI, A.; SARRADELL, J.; BERMÚDEZ, R.; QUIROGA, M.I.

DISEASES OF AQUATIC ORGANISMS

INTER-RESEARCH

Año: 2011 vol. 96 p. 61 - 68

0177-5103

An external pinkish growing mass that emerged from the right nostril of an adult goldfish (Carassius auratus L.) was evaluated by means of light microscopy and immunohistochemistry. The neoplasm presented a well-developed fibrovascular stroma associated with solid cell nests and a great amount of Flexner-Wintersteiner rosettes. Around them myelinated fibres were observed. Neoplastic cells showed a prominent degree of nuclear atypia and low mitotic activity. The latter was in agreement with the low positivity of tumour cells to anti-proliferating cell nuclear antigen antibody. Immunohistochemistry also revealed anti-neuronal nitric oxide shyntase, -S100 protein, -neuropeptide Y, and –cytokeratin immunoreactivity in tumour cells as well as in normal olfactory epithelium of goldfish control sections. Histopathological and immunohistochemical findings strongly suggest a diagnosis of an olfactory neuroblastoma (ONB). To our knowledge this is the first description of ONB in goldfish.