Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries

MORGAN, BROOKS W.; GRIGSBY, MATTHEW R.; SIDDHARTHAN, TRISHUL; CHOWDHURY, MUHAMMAD; RUBINSTEIN, ADOLFO; GUTIERREZ, LAURA; IRAZOLA, VILMA; MIRANDA, J. JAIME; BERNABE-ORTIZ, ANTONIO; ALAM, DEWAN; WISE, ROBERT A.; CHECKLEY, WILLIAM

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MOSBY-ELSEVIER

Año: 2019 vol. 143 p. 1598 - 1606

0091-6749

Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. Objective: We aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs). Methods: We compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV 1 /forced vital capacity ratio below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO as having both. Results: The prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV 1 %,