Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies

KAMENAR, KATARINA; HOSSEN, SHAKIR; GUPTE, AKSHAY N.; SIDDHARTHAN, TRISHUL; POLLARD, SUZANNE; CHOWDHURY, MUHAMMAD; RUBINSTEIN, ADOLFO L.; IRAZOLA, VILMA E.; GUTIERREZ, LAURA; MIRANDA, J JAIME; BERNABE-ORTIZ, ANTONIO; ALAM, DEWAN; KIRENGA, BRUCE; JONES, RUPERT C.; VAN GEMERT, FREDERIK; WISE, ROBERT A.; CHECKLEY, WILLIAM

Thorax

NLM (Medline)

Año: 2022 vol. 77 p. 1088 - 1097

BACKGROUND: Risk factors for COPD in high-income settings are well understood; however, less attention has been paid to contributors of COPD in low-income and middle-income countries (LMICs) such as pulmonary tuberculosis. We sought to study the association between previous tuberculosis disease and COPD by using pooled population-based cross-sectional data in 13 geographically diverse, low-resource settings. METHODS: We pooled six cohorts in 13 different LMIC settings, 6 countries and 3 continents to study the relationship between self-reported previous tuberculosis disease and lung function outcomes including COPD (defined as a postbronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) below the lower limit of normal). Multivariable regressions with random effects were used to examine the association between previous tuberculosis disease and lung function outcomes. RESULTS: We analysed data for 12 396 participants (median age 54.0 years, 51.5% male); 332 (2.7%) of the participants had previous tuberculosis disease. Overall prevalence of COPD was 8.8% (range 1.7%-15.5% across sites). COPD was four times more common among those with previous tuberculosis disease (25.7% vs 8.3% without previous tuberculosis disease, p