INVESTIGADORES
ROMERO Eder Lilia
artículos
Título:
Nanomedicines against Chagas disease: an update on therapeutics, prophylaxis and diagnosis
Autor/es:
MARIA JOSE MORILLA AND EDER LILIA ROMERO
Revista:
NANOMEDICINE
Editorial:
FUTURE MEDICINE LTD
Referencias:
Lugar: Londres; Año: 2015 vol. 10 p. 465 - 481
ISSN:
1743-5889
Resumen:
Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi. After a mostly clinically silent acute phase, the disease becomes a lifelong chronic condition that can lead to chronic heart failure and thromboembolic phenomena followed by sudden death. Antichagasic treatment is only effective in the acute phase but fails to eradicate the intracellular form of parasites and causes severe toxicity in adults. Although conventional oral benznidazol is not a safe and efficient drug to cure chronic adult patients, current preclinical data is insufficient to envisage if conventional antichagasic treatment could be realistically improved by a nanomedical approach. This review will discuss how nanomedicines could help to improve the performance of therapeutics, vaccines and diagnosis of Chagas disease.
