Molecular and Cellular Mechanisms of Synaptopathies: Emerging Synaptic aging-related molecular pathways in Neurological Disorders

CARLOS CRUCHAGA; LAURA IBANEZ; DARIO MASCHI; H.R QUINTÁ

Frontiers Media SA.

Año: 2023 p. 150

9782832533420

v>Despite the enormous advances made in our understanding of neurological disorders,a knowledge gap still exists that prevents the scientific community from linking clinicalmanifestations with actual cellular neuropathological changes. This connection is especiallycrucial for pathologies like Alzheimer’s disease (AD), which has a 10–20 year preclinicalperiod offering an extended window for potential interventions (McKhann et al., 1984;Sperling et al., 2011). However, the preclinical period has been challenging to explore dueto the lack of specific prognostic and predictive biomarkers.To identify disease progression biomarkers, we must diligently explore and identifynew causal genes and pathways associated with the disease. Furthermore, by understandingthese pathologies’ mechanistic, we will speed up the development of new disease-modifyingtherapies. Future advances in this endeavor will necessitate the collaborative efforts ofresearchers from diverse backgrounds. This diversity is reflected in our editorial panel andamong the contributors to this topic. Our Frontiers Research Topic, entitled “Molecular andcellular mechanisms of synaptopathies: emerging synaptic aging-related molecular pathways inneurological disorders”, comprises original research articles from experts in the neurosciencefield. These experts explore novel brain disease-related pathways that could serve as potentialtherapeutic targets. The number and originality of these contributions highlight the interestand ongoing activity in this area of investigation.