Nanoarchaeosomes in Drug Delivery

ROMERO, EL; MORILLA, MJ

Book cover Pharmaceutical Nanobiotechnology for Targeted Therapy

Springer

Año: 2022; p. 100 - 138

Nanoarchaeosomes are roughly smaller than 600-nm-diameter vesicles, having a mono- or oligolamellar monolayer or a bilayer membrane, made of pure archaeolipids, or in combination with other amphipathic molecules. They share morphology with liposomes but exhibit different properties, from their lipid stereoisomerism, their reactivity in front to chemical and physical agents, to their membrane fluidity and permeability, besides their heterogeneous compositions, considerably wider than those of liposomes. Such differences make them attractive as biomaterials constituting new lipid-based nanomedicines offering high structural stability and simple preparation at a lab and industrial scale, two disadvantages of a eukaryote or bacterial lipids-based nanomedicines. This chapter offers first a snapshot of archaea, since each gender, according to its habitat and metabolism, produces a given type or archaeolipid that will be responsible for the specific characteristics of each type or nanoarchaeosome. This is followed by an updated revision on the preclinical applications of nanoarchaeosomes in drug delivery.