NEUROSPHERE IN VITRO APPROACH TO STUDY HYALURONAN MODULATION AS A POTENTIAL THERAPY FOR THE IMPROVEMENT OF OLIGODENDROGLIAL DIFFERENTIATION IN DEMYELINATING DISEASES.

MOLINARI Y; PIBUEL M; BYRNE A.; POODTS D; DIAZ, M; LOMPARDÍA S; SILVESTROFF L; FRANCO P

Buenos Aires

Congreso; V International Congress in Translational Medicine; 2021

Master Program in Biomedical Sciences (IMBS)

In Multiple Sclerosis (MS) the immune-mediated oligodendrocyte damage leads to myelin loss and neurodegeneration. Current treatments are ineffective for the treatment of progressive forms of MS. As MS lesions were shown to contain hyaluronan deposits that inhibit oligodendroglial maturation and remyelination, we tested if hyaluronan depletion could improve oligodendrogenesis from neural stem and progenitor cells (NSC/NPC).