Dendronization of 4,7,10-Trioxa-1,13-Tridecanediamine: Synthesis And Characterization

PABLO FROIMOWICZ; MIRIAM C STRUMIA; ALESSANDRO GANDINI; TEODORO KAUFMAN

Conferencia; Third International Conference on Supramolecular Science and Technology; 2002

Recently, functionalization of central core molecules using an iterative method of the dendrimers chemistry attracts increasing interest due to their numerous advantage just known. In addition, end-functional multiarm polymers possess unusually high functionality that permits further modification or cross-linking or they may lead to  peculiar rheological  properties. Functional  poly(ethylene oxide) (PEO) polymers are regarded as a particularly promising class of materials, since they present variable building blocks for structured polymer networks, e.g. hidrogels or amphiphilic network systems. Due to the excellent biocompatibility of PEO, both the macromonomers precursors and the resulting networks  are of interest for biomedical and pharmaceutical applications. In this context, Merrill et al., recently demonstrated that due to their high functionality PEO stars attached to a surface permit size-selective protein adsorption. In this current paper we wish to describe the obtention of 4,7,10-trioxa-1,13-tridecanediamine dendronized with the aim to optimized the synthesis conditions starting of a simple molecule of a molecular weight and properties known. Then, the optimized conditions will be used for dendronization of  PEO oligomers with amine terminal groups (Jeffamines). The Figure 1 shows the synthetic scheme followed for the obtention of dendronized 4,7,10-trioxa-1,13-tridecanediamine. These new  class of functionalized building blocks could be used for modification of pre-formed polymers or for construction of new material with special applications properties.