Dendrimers as nano-controlled release system of siRNA.

A PAULA PEREZ, MARIA JOSE MORILLA, EDER L ROMERO

Florianópolis, Brasil

Congreso; V Encontro da SBPMat - Sociedade Brasileira de Pesquisas em Materiais; 2006

Sociedade Brasileira de Pesquisas em Materiais

Dendrimers have particular properties that make them useful as nano-controlled release system (nano-CRS) for siRNA. In this work, complexes formed by PAMAM dendrimers G4 and anti-GFP siRNA were characterized by electrophoresis retard, ethidium bromide displacement, size, cytotoxicity and gene silencing efficiency.for siRNA. In this work, complexes formed by PAMAM dendrimers G4 and anti-GFP siRNA were characterized by electrophoresis retard, ethidium bromide displacement, size, cytotoxicity and gene silencing efficiency.