EFFECT OF HIGH FAT DIET AND CHRONIC STRESS EXPOSURE ON LIPIDIC METABOLISM AND ADIPOKINES mRNA EXPRESION IN ADIPOSE TISSUE

MARCONE, PAULA; RUBINSTEIN, ROXANA; BURGUEÑO, ADRIANA LAURA; QUIROGA, SOFÍA; WALD, MIRIAM; GENARO, ANA M.

Virtual

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2021; 2021

SAIC, AAFE, SAI, Nanomed

Overweight and obesity are defined as abnormal or excessive fat accumulation caused by inadequate dietary habits and stress. Adipose tissue is a metabolically active organ that secrete adipokines involved in the maintenance of metabolic homeostasis. We have previously shown that mice fed with high fat diet (HFD) showed overweight and glucose intolerance. Chronic mild stress exposure (CMS) induced a decrease in body weight related to a decrease in caloric efficiency and worsening in glucose intolerance. The aim of this work was to study the participation of lipidic metabolism and adipokines expression in subcutaneous (SCAT) and visceral ?abdominal- adipose tissue (VAT) in glucose intolerance induced by HFD and-or CMS exposed C57Bl/6J male mice. HFD fed mice presented an increment in total cholesterol l (p