CONICET | Buscador de Institutos y Recursos Humanos

Prenatal stress could be programate HPA axis, potentially leading to altered metabolism in later life, associated with obesity and diabetes. This effects could be worsen in adulthoodif the individual doesn?t eat healthy. In the present work, we studied the effect of prenatal stress (PS) on metabolism and the impact of high fat diet (HFD). For this purpose pregnant BALB/c female mice were stressed by movement restriction during the last week ofpregnancy leaving a control group (NPS). After weaning, mice werefed with HFD or a standard diet (SD). After 8 weeks of diet, PS+HFD females showed a higher body weight (BW) than the other groups (p<0.001 vs NPS+HFD andPS+SD). PS males had a greater BW throughout the experiment(p<0.01 PS+HFD vs NPS+HFD and p<0.01 PS+SD vs NSP+SD).These animals did not present alterations in the glucose tolerancetest. When we performed an insulin tolerance test, in both genders,we observed an altered response linked to HFD rather than PS. Totalcholesterol was higher in HFD female groups (p<0.001 vs NPS+SDand p<0.05 vs PS+SD). In contrast, PS males had higher valuesindependently of the diet (p<0.001 vs NPS+SD and NPS+HFD).Similar results were found when we measure plasmatic triglycerides(p<0.001 vs NPS+SD and NPS+HFD). While triglycerides levels infemales increased with HFD (p<0.001 NPS+HFD vs. PS+HFD). Insummary: Females presented alterations due to PS but only observableunder HFD intake, such as an increase in body weight andelevated triglycerides. On the other hand, males showed metabolicdisorders mainly due to PS like an increased BW, total cholesteroland triglycerides. In conclusion, PS alters male metabolism in adulthood,regardless of the diet consumed. In females, the metabolicdisorders are evident with the intake of HFD. Finally, it?s possible report that PS generates sex and diet-dependent metabolic alterationsin mice of the BALB/c strain

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